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Mechanistically, macrophages post-MI recognize DAMPs released from necrotic cells through Toll-like receptors (TLRs), activating downstream signaling pathways such as the mTOR pathway and entering an activated state with increased energy demands (224, 226)
[Accessed 16th April 2026].
These effects are attributed to the rich profile of polyphenolic compounds, which confer potent antioxidant and anti-inflammatory properties
Although preclinical research indicates a favorable safety profile for BPC-157, even at high doses, the lack of comprehensive clinical data necessitates caution in research applications involving this peptide
